Association of a Haplotype in the <i>NR3C2</i> Gene, Encoding the Mineralocorticoid Receptor, With Chronic Central Serous Chorioretinopathy

Abstract

In this study, the variant rs2070951 and the GA haplotype in NR3C2 were associated with an increased risk for cCSC. Results of this genetic study support a possible role for the mineralocorticoid receptor in the pathogenesis of cCSC. Since these haplotypes have previously been associated with perceived stress, this study provides a clue to bridging clinical risk factors for cCSC to underlying genetic associations.