Concepedia

Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

Suyan Liu, Wei Zheng, Kui Wu, Yu Lin, Feifei Jia, Yang Zhang, Zhaoying Wang, Qun Luo, Yao Zhao, Fuyi Wang

Chemical Communications · 2017 · 24 citations · 23 references

DOI

Concepts

Abstract

A correlated ToF-SIMS and CLSM imaging strategy was developed to visualize the subcellular distribution of an organoruthenium anticancer complex, showing its accumulation in both cell membrane and nuclei and verifying its dual-targeting feature.

References

23

Highly Selective Binding of Organometallic Ruthenium Ethylenediamine Complexes to Nucleic Acids:  Novel Recognition Mechanisms

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Mass Spectrometric Imaging of Highly Curved Membranes During <i>Tetrahymena</i> Mating

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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

Matthew L. Steinhauser, Andrew P. Bailey, Samuel E. Senyo et al. · Nature · 2012 · 309 citations · Full text

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Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts

Jessica F. Frisz, Kaiyan Lou, Haley A. Klitzing et al. · Proceedings of the National Academy of Sciences · 2013 · 198 citations · Full text

, , +17