Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease

Abstract

The aortic media depends on an intrinsic NAD⁺ fueling system to protect against DNA damage and premature SMC senescence, with relevance to human thoracic aortopathy.