Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams

Abstract

The direct enantioselective vinylogous Michael addition of unsaturated γ-monosubstituted γ-lactams was realized by using chiral phase-transfer catalysis as a means to give enantioenriched γ,γ-disubstituted γ-lactams.