Concepedia

Two-photon fluorescent probe for revealing drug-induced hepatotoxicity via mapping fluctuation of peroxynitrite

Yong Li, Xilei Xie, Xiu’e Yang, Mengmeng Li, Xiaoyun Jiao, Yuhui Sun, Xu Wang, Bo Tang

Chemical Science · 2017 · 197 citations · 34 references

DOIFull text

Open access

Concepts

Abstract

A peroxynitrite-specific two-photon fluorescent probe was developed for revealing drug-induced hepatotoxicity using peroxynitrite as a biomarker.

References

34

Two-Photon Laser Scanning Fluorescence Microscopy

Winfried Denk, James H. Strickler, Watt W. Webb · Science · 1990 · 9.4K citations

, , +17

Acetaminophen‐induced acute liver failure

Anne M. Larson, Julie Polson, Robert J. Fontana et al. · Hepatology · 2005 · 1.9K citations

, , +13

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Adam J. Shuhendler, Kanyi Pu, Lina Cui et al. · Nature Biotechnology · 2014 · 622 citations · Full text

, , +17

A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells

Fabiao Yu, Peng Li, Guangyue Li et al. · Journal of the American Chemical Society · 2011 · 569 citations

, , +17

Selective Visualization of the Endogenous Peroxynitrite in an Inflamed Mouse Model by a Mitochondria-Targetable Two-Photon Ratiometric Fluorescent Probe

Dan Cheng, Yue Pan, Lu Wang et al. · Journal of the American Chemical Society · 2016 · 491 citations

, , +17