Facile Synthesis of a MoS₂–Prussian Blue Nanocube Nanohybrid-Based Electrochemical Sensing Platform for Hydrogen Peroxide and Carcinoembryonic Antigen Detection

Abstract

Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS 2 -PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS 2 nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS 2 -based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (H 2 O 2 ) detection. More interestingly, MoS 2 -PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS 2 -based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL –1 . Moreover, the detection limit was calculated to be 0.54 pg mL –1 . The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS 2 -PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.