Facile Synthesis of a MoS₂–Prussian Blue Nanocube Nanohybrid-Based Electrochemical Sensing Platform for Hydrogen Peroxide and Carcinoembryonic Antigen Detection

Abstract

Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS₂-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS₂ nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS₂-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (H₂O₂) detection. More interestingly, MoS₂-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS₂-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL^-1. Moreover, the detection limit was calculated to be 0.54 pg mL^-1. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS₂-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.