Demethylating agent decitabine disrupts tumor-induced immune tolerance by depleting myeloid-derived suppressor cells

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

Bo Huang, Ping‐Ying Pan, Qingsheng Li et al. · Cancer Research · 2006 · 1.4K citations

Life Sciences, Immunology, Oncology +17

Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

Hui Yang, Carlos E. Bueso‐Ramos, Courtney DiNardo et al. · Leukemia · 2013 · 684 citations · Full text

Medicine, Hematology, Oncology +10

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

Paolo Serafini, Stephanie Mgebroff, Kimberly Noonan et al. · Cancer Research · 2008 · 665 citations · Full text

Life Sciences, Immunology, Oncology +17

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13

Steven L. Highfill, Paulo C. Rodrı́guez, Qing Zhou et al. · Blood · 2010 · 473 citations

Life Sciences, Cell Biology, Immunology +15

DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling

Guoping Fan, Keri Martinowich, Mark H. Chin et al. · Development · 2005 · 420 citations

Medicine, Molecular Biology, Neuroscience +17