Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells

Abstract

Activated STAT3 triggered miR-21 transcription<italic>via</italic>binding to its promoter. ISL induced PIAS3 expression, a specific inhibitor of activated STAT3, leading to inhibition of STAT3 signaling and subsequent miR-21 transcription in breast cancer cells.