Pathomechanisms of anti–cytosolic 5′‐nucleotidase 1<scp>A</scp> autoantibodies in sporadic inclusion body myositis

Abstract

Our cell-based assay is useful for anti-cN1A autoantibodies detection. Patients with anti-cN1A autoantibodies demonstrated unique clinicopathological features. In vitro and in vivo passive immunization model results suggest that anti-cN1A autoantibodies may affect protein degradation in myofibers. Ann Neurol 2017;81:512-525.