Concepedia

Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

Fan Liu, Zhiyao Wang, Yue Qiu, Min Wei, Chunyan Li, Yikuan Xie, Le Shen, Yuguang Huang, Chao Ma

Journal of Neuroinflammation · 2017 · 80 citations · 37 references

DOIFull text

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Abstract

MyD88-dependent TIR pathway in the DRG and SDH may play a role in CCI-induced neuropathic pain. MyD88 might serve as a potential therapeutic target for neuropathic pain.

References

37

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Gary J. Bennett, Yuanyu Xie · Pain · 1988 · 5.3K citations

, , +25

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

Ruslan Medzhitov, Paula Preston‐Hurlburt, Elizabeth B. Kopp et al. · Molecular Cell · 1998 · 1.6K citations · Full text

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

Marta Muzio, Jian Ni, Ping Feng et al. · Science · 1997 · 1.2K citations

, , +21

Nociceptors Are Interleukin-1β Sensors

Alexander M. Binshtok, Haibin Wang, Katharina Zimmermann et al. · Journal of Neuroscience · 2008 · 642 citations · Full text

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

Kimberly Burns, Fabio Martinon, Christoph Esslinger et al. · Journal of Biological Chemistry · 1998 · 627 citations · Full text