Prospective evaluation of a week one overnight metyrapone test with subsequent dynamic assessments of hypothalamic‐pituitary‐adrenal axis function after pituitary surgery

Abstract

Overnight metyrapone test within the first week after pituitary surgery was no better than an early morning cortisol level at predicting glucocorticoid requirement at 6 months. OMT at week 6 demonstrated recovery of HPA axis in a substantial proportion of participants who failed earlier assessments; thus, definitive testing should be delayed until 6 weeks post-operatively.