MRI reduces variation of contouring for boost clinical target volume in breast cancer patients without surgical clips in the tumour bed

Abstract

Abstract Background Omitting the placement of clips inside tumour bed during breast cancer surgery poses a challenge for delineation of lumpectomy cavity clinical target volume (CTV LC ). We aimed to quantify inter-observer variation and accuracy for CT- and MRI-based segmentation of CTV LC in patients without clips. Patients and methods CT- and MRI-simulator images of 12 breast cancer patients, treated by breast conserving surgery and radiotherapy, were included in this study. Five radiation oncologists recorded the cavity visualization score (CVS) and delineated CTV LC on both modalities. Expert-consensus (EC) contours were delineated by a senior radiation oncologist, respecting opinions of all observers. Inter-observer volumetric variation and generalized conformity index (CI gen ) were calculated. Deviations from EC contour were quantified by the accuracy index (AI) and inter-delineation distances (IDD). Results Mean CVS was 3.88 +/− 0.99 and 3.05 +/− 1.07 for MRI and CT, respectively (p = 0.001). Mean volumes of CTV LC were similar: 154 +/− 26 cm 3 on CT and 152 +/− 19 cm 3 on MRI. Mean CI gen and AI were superior for MRI when compared with CT (CI gen : 0.74 +/− 0.07 vs. 0.67 +/− 0.12, p = 0.007; AI: 0.81 +/− 0.04 vs. 0.76 +/− 0.07; p = 0.004). CI gen and AI increased with increasing CVS. Mean IDD was 3 mm +/− 1.5 mm and 3.6 mm +/− 2.3 mm for MRI and CT, respectively (p = 0.017). Conclusions When compared with CT, MRI improved visualization of post-lumpectomy changes, reduced interobserver variation and improved the accuracy of CTV LC contouring in patients without clips in the tumour bed. Further studies with bigger sample sizes are needed to confirm our findings.