Journal of chemical and pharmaceutical research · 2010 · 11 citations · 0 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistryStructure-activity RelationshipsHeterocyclic ChemistryStructure-activity Relationship AnalysisAldehydesAntimicrobial Drug DevelopmentDiazonium SaltsNovel Antibacterial AgentsSpectral Element Analysis
In the present investigation, a series of uracil formazans (5a-r) were synthesized by condensation of schiff base (4a-c) and diazonium salt of various substituted aromatic amines. The intermediate schiff base (4a-c) was itself synthesized by condensation of (6-hydrazino-3-methyl uracil) with various aromatic aldehydes (3a-c). The structures of the compounds have been confirmed by elemental analysis and spectral analysis. Newly synthesized compounds were screened for their antimicrobial activities