Photoredox-catalyzed oxytrifluoromethylation of allenes: stereoselective synthesis of 2-trifluoromethylated allyl acetates

Abstract

We have developed novel oxytrifluoromethylation of aryl-substituted allenes by photoredox catalysis. The present photocatalytic system allows direct and stereoselective synthesis of 2-CF₃-allyl acetates bearing tetrasubstituted CF₃-alkene scaffolds in a single operation. The obtained CF₃-allyl acetates can be applied to further functionalization as CF₃-containing building blocks.