20:T495,Three body lotions (water-in-oil type) differing only in the emulsifier content were subjected to rheological measurements and sensory analysis with the aim to obtain coupling between the selected rheological characteristics and sensory factors. Both methods proved different behaviour of the samples caused by the difference in the emulsifying compound. To detect the relations between rheological (application of the power law model) and sensory variables, the four most important characteristics from sensory assessment (ease of pouring from the bottle, ease of spreading on a palm, thickness, and ease of spreading on back of hand) were selected. A close coupling (and hence mutual substitution) was found between consistency parameterkand thickness,kand the ease of pouring from the bottle, and alsokand the mean droplet size.21:T4e0,Often barrier creams (BC) do not fulfil their protecting behaviour, even when promised by the manufacturers. Therefore, it is of great importance to develop standardized in vivo techniques to prove the potency of BC in humans. In the present study, 3 promising techniques for the analysis of BC were evaluated: laser scanning microscopy, laser doppler flowmetry, and the tape-stripping procedure. Sodium fluorescein and glycerol trinitrate acted as hydrophilic model-penetrating substances. By means of these methods, 3 different BC were tested and compared for their potency. The investigations showed that primarily the tape-stripping procedure and also the laser scanning microscopy are promising tools for the evaluation of BC. In contrast, the laser doppler flowmetry represents a less feasible technique. In addition, the evaluation of BC showed that Vaseline enfolds a 100% barrier on the skin surface for the penetration of a hydrophilic dye, whereas BC1 only partially showed a protective effect and BC2 exhibited almost no potency. In conclusion, it can be referred that laser scanning microscopy and the tape-stripping procedure represent 2 non-invasive in vivo techniques, which enable a fast investigation concerning the potency of BC.

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