Water-controlled selective preparation of α-mono or α,α′-dihalo ketones via catalytic cascade reaction of unactivated alkynes with 1,3-dihalo-5,5-dimethylhydantoin

Abstract

An efficient protocol for the selective synthesis of α-mono or α,α′-dihalo ketones <italic>via</italic> a water-controlled chemodivergent and regiospecific cascade reaction has been developed.