Publication | Open Access

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation

Hypoxia-selective ActivationPharmaceutical ChemistryAldo-keto ReductaseBiochemistryAldehyde DehydrogenaseMedicineOridonin ProdrugsReactive Oxygen SpecieIndolequinone MoietyPharmacologyRedox BiologyDrug DiscoveryOxidative Stress