Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with¹H-MRS and Pittsburgh Compound-B PET

Abstract

This study found an association between cortical glutathione levels and brain amyloidosis in healthy older adults, suggesting a potential role for ¹H-MR spectroscopy measures of glutathione as a noninvasive biomarker of early Alzheimer disease pathogenesis.