Pd-Catalyzed Direct <i>ortho</i>-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group

Abstract

The Pd-catalyzed direct C(sp²)-H arylation of aromatic ketones using a transient directing group is described. The ketimine/carboxylate bidentate directing group in situ generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C-H arylation, which shows extensive substrate compatibility.