Intensification of marrubiin concentration by optimization of microwave-assisted (low CO ₂ yielding) extraction process for <i>Marrubium vulgare</i> using central composite design and antioxidant evaluation

Abstract

The CCD can be successfully applied to optimize the extraction parameters (MAE) for M. vulgare. Moreover, in terms of environmental impact, the MAE technique could be assumed as a 'Green approach' because the MAE approach for extraction of plant released only 92.3 g of CO₂ as compared to 3207.6 g CO₂ using the Soxhlet method of extraction.