Concepedia

Discovery of 1,3-diyne compounds as novel and potent antidepressant agents: synthesis, cell-based assay and behavioral studies

Kaiqing Ma, Miao Yan-hong, Xiao Li, Yuzhi Zhou, Xiaoxia Gao, Xiang Zhang, Jianbin Chao, Xuemei Qin

RSC Advances · 2017 · 10 citations · 13 references

DOIFull text

Open access

Concepts

Abstract

1,3-Diynes compound <bold>7a</bold> protected the corticosterone-injured PC12 cells through regulation of the apoptosis related proteins and exerted antidepressant effect in mice forced swim test in a concentration-dependent manner.

References

13

Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis

Bo Zhang, Yao Wang, Sheng‐Ping Yang et al. · Journal of the American Chemical Society · 2012 · 78 citations · Full text

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Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells

Bingqing Zeng, Yiwen Li, Bo Niu et al. · Journal of Molecular Neuroscience · 2016 · 60 citations

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Cytoprotective effect is one of common action pathways for antidepressants.

Yunfeng Li, Yanqin Liu, Wen-Chao Huang et al. · PubMed · 2003 · 59 citations

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Future Directions for Serotonin and Antidepressants

Francesc Artigas · ACS Chemical Neuroscience · 2013 · 57 citations · Full text

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Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site

Wolfgang Heydenreuter, Elena Kunold, Stephan A. Sieber · Chemical Communications · 2015 · 55 citations · Full text

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