Clinical and Pathological Studies of Five Autopsied Cases of Aortitis Syndrome

Abstract

The clinical findings and the necropsy reports of 5 cases of aortitis syndrome have been presented. In addition to the typical arterial changes, diffuse myocardial fibrosis with marked left ventricular hypertrophy was seen at necropsy. The relationship between these cardiac lesions and aortitis syndrome was discussed. The development of aortic valvular insufficiency in this disease was not infrequently found, and was thought to be due to the dilatation of valvular ring and/or the extension of the inflammatory change of the aorta to the aortic valve itself. The prognosis of the disease seems to be dependent largely on the severity of heart failure, aortic insufficiency and hypertension.