Phosphine‐Mediated Dimerization of Conjugated Ene‐Yne Ketones: Stereoselective Construction of Dihydrobenzofurans

Abstract

Abstract A new strategy for the phosphine‐mediated dimerization of conjugated ene‐yne ketones to produce functionalized dihydrobenzofurans has been developed, affording diversified 4,5‐dihydrobenzofurans in moderate to excellent yields with high diastereoselectivities under mild conditions. This new synthetic method can tolerate a variety of functional groups and can be performed on a gram scale and in an asymmetric variant using the chiral phosphine Xyl‐BINAP to give the desired products with up to 94% ee . magnified image