The Journal of Antibiotics · 1983 · 21 citations · 0 references
MedicineMedicinal ChemistryPharmacologyCancer PharmacologyDrug DiscoverySynthetic Medicinal ChemistryAntitumor AntibioticsPharmacodynamics Of Anticancer AgentsPharmacodynamics Of Anticancer DrugsPharmacokinetics Of Anticancer DrugsAntibiotic DiscoveryAntibiotic Mechanisms Of ActionAnticancer ActivityBiological Activity FeaturesSubstituent Effects On Biological Activity
Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.