Brønsted‐Acid‐Catalyzed Multicomponent One‐Pot Reaction: Efficient Synthesis of Polysubstituted 1,2‐Dihydropyridines

Abstract

Abstract An efficient method for the synthesis of 1,2‐dihydropyridine derivatives from simple and readily available aromatic ketones, DMF, amines and propargylic alcohols has been developed via a Brønsted‐acid‐catalyzed multicomponent one‐pot reaction. This reaction proceeded smoothly under metal‐ and ligand‐free conditions in good yields, leading to functional organic molecules, via a self‐organized sequence.