Assessment of early combination effects of colistin and meropenem against<i>Pseudomonas aeruginosa</i>and<i>Acinetobacter baumannii</i>in dynamic time-kill experiments

Abstract

Combination effects were frequently found with colistin and meropenem against P. aeruginosa and A. baumannii in time-kill experiments but were not detected with the checkerboard method. We propose that the early dynamics of bacterial killing and growth, which may be of great clinical importance, should be considered in future in vitro combination studies.