Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia

Multistate Point-Prevalence Survey of Health Care–Associated Infections

Shelley S. Magill, Jonathan R. Edwards, Wendy Bamberg et al. · New England Journal of Medicine · 2014 · 3.9K citations · Full text

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

Kristin Westphalen, Galina A. Gusarova, Mohammad Naimul Islam et al. · Nature · 2014 · 437 citations · Full text

Inflammation, Lung Inflammation, Innate Immune System +9

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

William L. Perry, Carolyn M. Hustad, Debra A. Swing et al. · Nature Genetics · 1998 · 329 citations

Knockout Mouse, Systems Biology, Protein Function +9

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

Deyu Fang, Chris Elly, Baixue Gao et al. · Nature Immunology · 2002 · 328 citations

Inflammation, Th2 Differentiation, Allergy +11

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Noula Shembade, Nicole S. Harhaj, Neal G. Copeland et al. · Nature Immunology · 2008 · 266 citations

Inflammation, Signal Transduction, Autoimmune Disease +11