Biomaterials Science · 2017 · 125 citations · 36 references
Natural SciencesBioengineeringMaterials ScienceDrug DeliveryNanobiotechnologyNanomaterialsNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle SynthesisPhotodynamic TherapyAntibacterial NanomaterialsAntimicrobial NanomedicineAntimicrobial Photodynamic TherapyMultifunctional NanomaterialsMultifunctional NanoparticlesMultifunctional NanoplatformsPhotodynamic Therapy NanomaterialsSinglet Oxygen Generation
layer, which improved the biocompatibility of the UCNPs, surrounded the yolk structure, with a cavity space which had a high efficiency of loading photosensitizers. Synergistic PDT and sonodynamic therapy (SDT) improved the photosensitizer utilization rate. As a result, a greater inhibition rate was observed when antibiotic-resistant bacteria were treated with a combined therapy (100%) compared with either the PDT (74.2%) or SDT (70%) alone. Our data indicate that the multifunctional NPs developed in this study have the potential for use in the clinical synergistic PDT-SDT treatment of infectious diseases caused by antibiotic-resistant bacteria.
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