Comparative pharmacokinetics of chlorogenic acid in beagles after oral administrations of single compound, the extracts of <i>Lonicera japanica</i> , and the mixture of chlorogenic acid, baicalin, and <i>Forsythia suspense</i>

Abstract

Co-existing compounds in SHL have no effect on the absorption of ChA, while the concomitant compounds in Lonicera japanica could decrease that of ChA. ChA in Beagles might have high biological transformation.