Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012

TLDR

Metabolic syndrome is a cluster of cardiometabolic risk factors associated with increased risk of multiple chronic diseases, including cancer and cardiovascular disease. The study aimed to estimate overall, race‑ and sex‑specific prevalence of metabolic syndrome and assess its trends from 1988 to 2012 using NHANES data. Metabolic syndrome was defined as having at least three of five components—waist circumference, triglycerides, HDL cholesterol, blood pressure, fasting glucose—and prevalence was estimated across three periods (1988‑1994, 1999‑2006, 2007‑2012) using NHANES data. Prevalence of metabolic syndrome increased from 25.3% in 1988‑1994 to 34.2% in 2007‑2012, with non‑Hispanic black men less likely and non‑Hispanic black women more likely than non‑Hispanic white counterparts, and low education and older age independently associated with higher risk, resulting in over one‑third of U.S.

Abstract

Metabolic syndrome is a cluster of cardiometabolic risk factors associated with increased risk of multiple chronic diseases, including cancer and cardiovascular disease. The objectives of this study were to estimate the prevalence of metabolic syndrome overall, by race and sex, and to assess trends in prevalence from 1988 through 2012.We analyzed data from the National Health and Nutrition Examination Survey (NHANES) for 1988 through 2012. We defined metabolic syndrome as the presence of at least 3 of these components: elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, high blood pressure, and elevated fasting blood glucose. Data were analyzed for 3 periods: 1988-1994, 1999-2006, and 2007-2012.Among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988-1994 to 2007-2012, increasing from 25.3% to 34.2%. During 2007-2012, non-Hispanic black men were less likely than non-Hispanic white men to have metabolic syndrome (odds ratio [OR], 0.77; 95% confidence interval [CI], 0.66-0.89). However, non-Hispanic black women were more likely than non-Hispanic white women to have metabolic syndrome (OR, 1.20; 95% CI, 1.02-1.40). Low education level (OR, 1.56; 95% CI, 1.32-1.84) and advanced age (OR, 1.73; 95% CI, 1.67-1.80) were independently associated with increased likelihood of metabolic syndrome during 2007-2012.Metabolic syndrome prevalence increased from 1988 to 2012 for every sociodemographic group; by 2012, more than a third of all US adults met the definition and criteria for metabolic syndrome agreed to jointly by several international organizations.