Journal of the Royal Statistical Society Series B (Statistical Methodology) · 2009 · 63 citations · 19 references
ComputingBiostatisticsBayesian Data AnalysisStochastic ProcessesTime Series AnalysisDiffusion ProcessesMarkov Chain Monte CarloMolecular DynamicsMonte Carlo MethodsMonte Carlo SimulationAsymptotic AnalysisDynamicsGibbs SamplingInference For Diffusion ProcessesMolecular DiffusionParameter Estimation For DiffusionsParameter Estimation For Stochastic Differential EquationsTransition Density Estimation
Summary Hypoelliptic diffusion processes can be used to model a variety of phenomena in applications ranging from molecular dynamics to audio signal analysis. We study parameter estimation for such processes in situations where we observe some components of the solution at discrete times. Since exact likelihoods for the transition densities are typically not known, approximations are used that are expected to work well in the limit of small intersample times Δt and large total observation times N Δt. Hypoellipticity together with partial observation leads to ill conditioning requiring a judicious combination of approximate likelihoods for the various parameters to be estimated. We combine these in a deterministic scan Gibbs sampler alternating between missing data in the unobserved solution components, and parameters. Numerical experiments illustrate asymptotic consistency of the method when applied to simulated data. The paper concludes with an application of the Gibbs sampler to molecular dynamics data.
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Brownian motion in a field of force and the diffusion model of chemical reactions
H. A. Kramers · Physica · 1940 · 8.6K citations
Natural Sciences, Chemistry, Physics +16
Monte Carlo Statistical Methods
Hoon Kim, Christian P. Robert, George Casella · Technometrics · 2000 · 5.6K citations