Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization

Abstract

These results demonstrate that ApoE2 and ApoE3, but not ApoE4, have proangiogenic effects, and the increased expression of ApoE in the vitreous humor of patients with PDR and DME indicates that ApoE2 and ApoE3 are involved in the development of retinal neovascularization in eyes.