C₅‐Alkyl‐1,3,4‐Oxadiazol‐2‐ones Undergo Dealkylation upon Nitrogen Insertion to Form 2<i>H</i>‐1,2,4‐Triazol‐3‐ones: Synthesis of 1,2,4‐Triazol‐3‐one Hybrids with Triazolothiadiazoles and Triazolothiadiazines

Abstract

The present study emphasizes on the dealklylation of 3‐aryl‐5‐alkyl‐2‐oxo‐Δ 4 ‐1,3,4‐oxadiazoles when reacted with formamide resulting in the formation of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐ones as major product. Subsequent reactions of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐one gave triazolo[3,4‐ b ][1,3,4]thiadiazoles and triazolo[3,4‐ b ][1,3,4]thiadiazines derivatives incorporated with 1,2,4‐triazol‐3‐one.