PEDIATRICS · 2005 · 281 citations · 48 references
PharmacyPediatricsToxicologyEnvironmental HealthEnvironmental ToxicologyHeavy Metal ToxicologyExposure AssessmentHeavy Metal NeurotoxicityLead ExposureLead PoisoningLead ToxicologyPediatric Heavy Metal PoisoningBlood Lead Level TestingChildhood Lead ExposureCognitive Effects Of LeadLead Exposure ControlLead Exposure PreventionLead Exposure RiskPediatric Lead PoisoningStabilization
Although fatal lead encephalopathy has disappeared and blood lead levels have fallen, about 25 % of US children still live in deteriorated lead‑paint housing and are at risk of exposure that can impair cognition even at concentrations below 10 µg/dL, with no identified safe threshold. The focus in childhood lead‑poisoning policy should shift from case identification and management to primary prevention, aiming for safe housing for all children. Housing stabilization and repair can interrupt exposure in most cases. Most US children should have their blood lead concentration measured at least once, and evidence‑based guidance now exists for managing those with increased exposure.
Fatal lead encephalopathy has disappeared and blood lead concentrations have decreased in US children, but approximately 25% still live in housing with deteriorated lead-based paint and are at risk of lead exposure with resulting cognitive impairment and other sequelae. Evidence continues to accrue that commonly encountered blood lead concentrations, even those less than 10 microg/dL, may impair cognition, and there is no threshold yet identified for this effect. Most US children are at sufficient risk that they should have their blood lead concentration measured at least once. There is now evidence-based guidance available for managing children with increased lead exposure. Housing stabilization and repair can interrupt exposure in most cases. The focus in childhood lead-poisoning policy, however, should shift from case identification and management to primary prevention, with a goal of safe housing for all children.
48
The Long-Term Effects of Exposure to Low Doses of Lead in Childhood
Herbert L. Needleman, Alan Schell, Alan Leviton et al. · New England Journal of Medicine · 1990 · 1.2K citations · Full text
Pharmacy, Psychology, Toxicology +17
Bone Lead Levels and Delinquent Behavior
Herbert L. Needleman · JAMA · 1996 · 601 citations