How to handle adsorption of cerebrospinal fluid amyloid β (1–42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio - Concepedia

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How to handle adsorption of cerebrospinal fluid amyloid β (1–42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio

71

Citations

31

References

2017

Year

Eline A.J. Willemse, Kees van Uffelen, Britta Brix, Sebastiaan Engelborghs, Hugo Vanderstichele, Charlotte E. Teunissen

Alzheimer s & Dementia

Abstract

We confirmed that adsorption of CSF Aβ<sub>1-42</sub> during preanalytical processing is an important confounder. However, use of the Aβ<sub>1-42</sub>/Aβ<sub>1-40</sub> ratio overcomes this effect and can therefore contribute to increased diagnostic accuracy.

References

	Year	Citations

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