Association analysis of <i>APO</i> gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population

Abstract

// Rongjun Xiao 1,* , Shuaiqi Sun 1,* , Jiayi Zhang 2 , Yongri Ouyang 2 , Ning Zhang 2 , Min Yang 2 , Tianbo Jin 2 and Ying Xia 1 1 Department of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou People&rsquo;s Hospital, Haikou, Hainan, China 2 School of Life Sciences, Northwest University, Xi&rsquo;an, Shaanxi, China 3 Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China * These authors have Contributed equally to this work Correspondence to: Tianbo Jin, email: // Ying Xia, email: // Keywords : APO; ischemic stroke; gene polymorphisms; case-control study; Chinese Han population Received : January 10, 2017 Accepted : February 13, 2017 Published : February 20, 2017 Abstract This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we geno&shy;typed 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the &chi;2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0.042 (OR = 1.406; 95%CI = 1.011-1.956), rs651821 with a p value of 0.007 (OR = 0.760; 95%CI = 0.622-0.929) and rs662799 with a p value of 0.006 (OR = 0.755; 95%CI = 0.618-0.923). In the genetic model analysis, we found the minor allele &ldquo;A&rdquo; of rs693 was associated with an increased ischemic stroke risk in the additive model and dominant model. The minor allele &ldquo;C&rdquo; of rs651821 was associated with a decreased ischemic stroke risk in the additive model. The minor allele &ldquo;G&rdquo; of rs662799 was associated with a decreased ischemic stroke risk in the additive model. Additionally, strong linkage was found in 3 blocks constituted by rs1042034, rs676210, rs693, rs673548 in APOB ; rs3791981, rs679899 in APOB ; and rs651821, rs662799, rs17120035 in APOA5 . Our data suggested that gene polymorphisms in the APO genes may exert influences ischemic stroke susceptibility in a Chinese Han population.