Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Abstract

In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references <i>Chloramphenicol</i> and <i>Trimethoprim</i>/<i>sulphamethoxazole</i>. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.