Chelation‐Assisted Palladium‐Catalyzed γ‐Arylation of Aliphatic Carboxylic Acid Derivatives

Abstract

Abstract A palladium(II)‐catalyzed protocol for the highly regioselective remote γ ‐C–H arylation of aliphatic carboxylic acid has been disclosed. The 8‐aminoquinoline moiety as an intramolecular bidentate chelator was found to be suitable for this γ ‐C–H arylation. Various aryl iodides successfully produced the regioselectively mono‐arylated products with negligible diarylation. Functional group tolerance and easy‐to‐handle reaction conditions make this method attractive. magnified image