Regulatory B Cells in Seropositive Myasthenia Gravis versus Healthy Controls

Abstract

It has been observed that the reduced number of B cells is able to produce IL-10 in MG patients but lesser than compared to HCs. The Bregs reduction mainly was regarded by the severity of disease status, which was highly significant and also by disease duration which was statistically significant as well. The findings of the measurement of B cell phenotype assay and frequencies of B cell subsets between MGs and HCs give us new ideas to develop B cell-mediated therapies of MG such as (1) isolated B cells of MGs could be cultured with steroids, e.g., dexamethasone <i>in vitro</i> to see if it induces the CD19⁺CD5⁺CD1d⁺ Breg cells, (2) it may observe whether induced CD19⁺CD5⁺CD1d⁺ Bregs have higher production of IL-10 and TGF-β1, as both are linked with disease severity, and (3) after completion <i>in vitro</i> steps, through further research <i>in vivo</i> to observe whether it improves the function of MG disease status.