Impaired Left Ventricular Global Longitudinal Strain in Patients with Heart Failure with Preserved Ejection Fraction: Insights from the RELAX Trial

Abstract

Impaired LV GLS is common among HFpEF patients, indicating the presence of covert systolic dysfunction despite normal LV ejection fraction. Impaired LV GLS was associated with biomarkers of wall stress and collagen synthesis and diastolic dysfunction but not with quality of life or exercise capacity, suggesting other processes may be more responsible for these aspects of the HFpEF syndrome.