Cytotoxicity of arsenic trioxide in single leukemia cells by time-resolved ICP-MS together with lanthanide tags

Abstract

A novel strategy using cisplatin as a viability dye together with conjugating lanthanide tags to marker proteins was developed to examine As₂O₃ cytotoxicity in single NB4/HL60 cells via ICP-MS. A positive correlation among intracellular arsenic contents, the ratios of apoptosis and death cells provides a basis for the design of more effective arsenic drugs.