Clinical and genetic factors predicting Dravet syndrome in infants with <i>SCN1A</i> mutations

Abstract

In individuals with <i>SCN1A</i> mutations, age at seizure onset appears to predict outcome better than mutation type. Because outcome is not predetermined by genetic factors only, early recognition and treatment that mitigates prolonged/repeated seizures in the first year of life might also limit the progression to epileptic encephalopathy.