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A Mathematical Description of Sublethal Damage Repair and Interaction During Continuous Low-Dose Rate Irradiation
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1994
Year
Mathematical DescriptionRadiation PhysicsRadiation EffectRadiation ExposureSublethal Damage RepairCell CycleMathematical FormalismRadiation ProtectionRadiation OncologyNuclear MedicineRadiologyHealth SciencesCell DivisionRadiation EffectsCell BiologyDosimetryCell SurvivalSurvival ProbabilitiesRadiobiologySystems BiologyMedicine
Abstract A mathematical formalism that calculates survival probabilities for cells exposed to ionising radiation while progressing through the mitotic cycle is described. The formalism, based on the linear quadratic expression -InS(D) = aD + ßD2, includes phase-specific cellular parameters and recovery constants for sublethal damage, the interaction between sublesions produced at different stages of the cell cycle, and the time spent by cells in each phase of the cycle while being irradiated. Survival curves calculated with this formalism are compared with model calculations where the overall survival probability is obtained (in the authors' view, incorrectly) as a simple product of phase specific probabilities.