Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

Abstract

Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf) 3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.