Publication | Open Access
Novel poly(ADP-ribose) polymerase inhibitor veliparib: biophysical studies on its binding to calf thymus DNA
28
Citations
43
References
2017
Year
New Anticancer DrugMolecular BiologyMedicinal ChemistryNucleic Acid ChemistryPolymerase Inhibitor VeliparibThymus DnaNovel PolyAnti-cancer AgentBiochemistryMolecular Biological MethodOligonucleotideDna ReplicationPolymerase InhibitorsDrug DevelopmentPharmacologyBiomolecular EngineeringPolymer-drug ConjugateNatural SciencesNucleic Acid AmplificationConformational PerturbationMedicineDrug Discovery
Veliparib, an new anticancer drug in the class of poly (ADP-ribose) polymerase inhibitors, intercalates partially and binds to ctDNA and induces moderate conformational perturbation of the DNA.
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