Green Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes

Abstract

Abstract Employing a green and efficient 2,2,2‐trifluoroacetophenone‐catalyzed oxidation of alkenes, which utilizes H 2 O 2 as the green oxidant, a novel and sustainable synthesis of indolines and pyrrolidines was developed. This constitutes a cheap, general and environmentally‐friendly protocol for the synthesis of substituted nitrogen‐containing heterocycles. A variety of substitution patterns, both aromatic and aliphatic moieties, are well tolerated leading to the desired nitrogen heterocycles in good to excellent yields. magnified image