Smoking modify the effects of polycyclic aromatic hydrocarbons exposure on oxidative damage to DNA in coke oven workers

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

Hiroshi Kasai, P. F. Crain, Yoshiyuki Kuchino et al. · Carcinogenesis · 1986 · 923 citations

Medicine, Genetics, Molecular Biology +17

Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons

F.J. Jongeneelen · The Annals of Occupational Hygiene · 2001 · 321 citations

Pharmacy, Environmental Sciences, Toxicology +15

Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung

S Asami · Carcinogenesis · 1997 · 290 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8‐hydroxy‐2′‐deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment

Marina Erhola, Shinya Toyokuni, K. Okada et al. · FEBS Letters · 1997 · 265 citations · Full text

Medicine, Cancer Biology, Oncology +13

Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells

Nisha Palackal, Seon Hwa Lee, Ronald G. Harvey et al. · Journal of Biological Chemistry · 2002 · 224 citations · Full text

Medicine, Biochemistry, Toxicology +16