Advanced Materials · 2017 · 188 citations · 24 references
EngineeringOrthopaedic SurgeryOrthopedic SurgeryCartilage RepairRegenerative MedicineTissue EngineeringBone RegenerationCartilage RegenerationCartilage Tissue EngineeringMesenchymal Stem Cell TherapyOsteochondral RepairRegenerative ScaffoldsAutologous Stem Cell TherapyCartilage Defect RepairCartilage Regeneration ScaffoldsOsteochondral Defect RepairOsteochondral RegenerationOsteochondral Repair ScaffoldsOsteochondral Tissue EngineeringScaffold-based Cartilage Regeneration
To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.
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A Stem Cell–Based Approach to Cartilage Repair
Kristen Johnson, Shoutian Zhu, Matthew S. Tremblay et al. · Science · 2012 · 790 citations