Angewandte Chemie International Edition · 2017 · 292 citations · 78 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst PreparationCatalyst SynthesisHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisFunctionalizationFused Heterocycle SynthesisHeterocycle FunctionalizationHeterocyclic CatalystsPalladium Catalysts
The first catalytic formal [5+4] cycloaddition to prepare nine-membered heterocycles is presented. Under palladium catalysis, the reaction of N-tosyl azadienes and substituted vinylethylene carbonates (VECs) proceeds smoothly to produce benzofuran-fused heterocycles in uniformly high efficiency. Highly diastereoselective functionalization of the nine-membered heterocycles through peripheral attack is also demonstrated.
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Diverse Methods for Medium Ring Synthesis
Gary A. Molander · Accounts of Chemical Research · 1998 · 407 citations