Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines

Abstract

Abstract An easily accessible prolinol derived ligand, ( S )‐bis(3,5‐bis(trifluoromethyl)phenyl)(pyrrolidin‐2‐yl)methanol, has been efficiently applied in the catalytic enantioselective addition of terminal alkynes to cyclic imines using dimethylzinc (Me 2 Zn) under mild reaction conditions. The developed catalytic system led to chiral propargylic sulfamidates with high yields (up to 97%) and excellent enantioselectivities (up to 97% ee). magnified image